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Cardiac marker POCT status quo(二)

Feb 16, 2018

POCT for heparin anticoagulation monitoring

Heparin monitoring is quite frequent in hospitalized patients, especially in patient care, and prolonged waiting blocks the rapid diagnosis of coagulation disorders and rapid and effective anticoagulation. Although POCT for heparin monitoring in China is relatively mature and is practically limited to the ACT assay, ACT is not the only option and the POCT assay by APTT provides this possibility. Heparin anticoagulation monitoring is interfered by many factors, such as excessive use of heparin, protamine, acquired factor defects, DIC, primary fibrinolysis and the like. Due to a wide range of causes, such as individual, instrument or reagent differences, it is difficult to establish the relationship between anticoagulant effect and prolonged agglutination time. Through the survey found that, POCT and automated instrumentation APTT correlation between the less than ideal, APTT consistency is far less than PT. Since INR is not calibrated, the APTT has an incomparable number of seconds, a slightly higher POCT than the automated coagulometer, and a wide range of measurements, making it inconvenient to compare between high values. The APTT test itself is not uniform due to the sensitivity of the reagents, the automated coagulometer combination of different APTT reagents for the same plasma results, and up to 200% difference in patients treated with heparin. POCT technology and automated coagulation analyzer with different methodological characteristics, even if the quality control specimens of a certain degree of correlation, the difference is difficult to ignore.

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