Benzodiazepine, which inhibits the reticular formation of the midbrain and stimulates the cortex (the network structure is related to the functional state of the ascending activation system, which can transmit stimulation impulses to the cortex through a non-specific diffuse projection system, maintain excitement, and maintain awakening ), inhibiting neuronal activity in the limbic system, attenuating its activation of the reticular structure and benefiting sleep. At the same time, the special effect on the limbic system can effectively alleviate emotional activities, and has a good effect on anxiety and insomnia.
Addiction, that is, drug dependence, has two main aspects: first, psychological dependence and physical dependence. Benzodiazepines can produce drug dependence, mainly due to: insomnia → benzodiazepine therapy → rebound insomnia → need to continue drug treatment → produce tolerance → need to increase drug dose treatment → drug dependence → The treatment cannot be terminated. These side effects are most likely to occur in short-acting benzodiazepines; second, long-acting benzodiazepines are markedly slow, and their inhibition of respiration and daytime residual effects are stronger. According to the US Food and Drug Administration It is stipulated that benzodiazepines should not be used as hypnosis for more than 4 weeks.