Cardiovascular inflammatory markers and its clinical application
Causes of atherosclerosis and coronary heart disease and clinical harm the already familiar to the human body, its diagnosis and treatment, early detection and intervention. Among the indicators in the evaluation of risk factors of coronary heart disease, high-sensitivity CRP (hsCRP) is receiving medical attention. CRP is an acute-phase protein in the human body, is minimal in normal serum, when there are acute inflammation, tissue damage and coronary heart disease cRP levels can be multiplied, be clinical as the best laboratory indicators of inflammation and infection. But the original cRP detection sensitivity is relatively poor, it is difficult to detect small changes in levels of cRP, and coronary heart disease early or only a slight injury in myocardial tissue cRP modest changes when original methods are difficult to find this kind of change. And a new generation of hyper-sensitivity cRP assay (hscRP) greatly improves sensitivity and accuracy, can accurately detect small changes in levels of CRP, the early detection of potential risk for cardiovascular disease. Generally, when used in cardiovascular risk assessment, hs-cRP<1.0mg/I for low risk; 1.o~3.0mg/l as medium risk, and >3. 0mg/l for the high level of danger. Hs-CRP used in combination with total concentration of bile alcohols, and HDL ratio to evaluate high-risk patients with coronary heart disease (cHD) risk with more objective value.