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TORCH Series Standard Detection Procedure

Mar 03, 2017

1.What is TORCH?

TORCH , is the abbreviation of a group of pathogenic microorganisms, includinges (TOX) , Others-B19, RV, CMV, HSV-I/II (IgMm/IgG), and affined toxoplasma gondii, idioblast and , rubella virus affinity pathogen. If a pregnant woman is confirmed to be infected with any kind of pathogen, she could spread the disease to her fetus so it caused intrauterine infection, and the embryo and fetus have severe symptom and sign. It can also cause abortion and although the baby survived after birth, it still has defects such as the central nervous system disorder. The chances of infection for the fetus. The chances of infection of the fetus is closely related to gestational weeks of pregnant woman being infected with pathogene and whether primary infection or not,etc.

2.TORCH test standard procedure

Standardized test process can provide the doctor’s correct diagnosis with strong laboratory evidence, so it can avoid embryo/fetus being aborted、premature birth、intrauterine growth retardation、dead fetus、deaths in newborns. Therefore, standardized testing process has positive effect on the normal development of fetus.

图片1.pngStandard procedure of TORCH testing(CMV as an example)

3.TORCH significance and result interpretation.

Monospecific anti-IgM is the earliest antibody after pathogene was infected. If IgM antibody is testing positive, it indicating that he/she may be infected with pathogene recently. Then the monospecific anti-IgG.appears and can exist in human body for long time. These reasons Due to like recurrent infections, low IgM acknowledgment, delaying acknowledgment, lacking,or Monospecific anti-IgM continuingly exist,etc, doctors can not confirm patients’ infection time only by  cause that separate IgM/IgG detection can not meet the doctor’s needs of confirming infection time of patient. The introduction of IgG affinity test provides confirmation of infection time with Lab evidence. Llow- affinedity anti-IgG indicates it appears early stage of infection. As time goes on, the anti-IgG and antigen are more complementary which is called High affinity antibodies. High affinity antibodies shows that the infection appears during within a few months or years. 

Therefore, TORCH IgM/IgG affinity test can distinguish primary infection from secondary infection effectively and offers evidence  to identifying and detecting difficult case (like recurrent infection, abnormal anti-IgM,etc.).